Campylobacter Jejuni - Free Essay Example

Sample details Pages: 5 Words: 1647 Downloads: 10 Date added: 2017/06/26 Category Medicine Essay Type Essay any type Level High school Did you like this example? Campylobacter Jejuni Campylobacter jejuni is one of a family of bacteria known as Campylobacteriaceae that collectively are responsible for a significant number of reported cases of gastroenteritis in the UK. Gastrointestinal infection with Campylobacter spp. can produce significant long term sequelae, such as reactive arthritis and the neurological condition Guillain-Barre Syndrome. Don’t waste time! Our writers will create an original "Campylobacter Jejuni" essay for you Create order This report will give a brief overview of campylobacter jejuni with regard to its microbiology, and the identification and management of campylobacter infection. Campylobacters were recognised as a cause of human illness in the 1970s, but were probably first identified in humans by Escherich in 1886, who identified spiral shaped bacteria of the colons of children who had died from a condition he called cholera infantum (Escherisch 1886). Veterinary research at the beginning of the twentieth century identified similar bacteria in livestock, and the bacteria (termed at the time vibrio or spirillium) was implicated in a number of reported cases in both animals and humans throughout the mid-twentieth century (Butzler 2004). The key breakthrough was reported in 1972, when Dekeyser and Butzler were able to isolate the bacteria now known as campylobacter jejuni from the stool of an infected patient (Dekeyser 1972). Campylobacter spp. are classified as part of rRNA superfamily VI, a cl assification of bacteria that also includes Helicobacter and Arcobacter (Vandamme 1991). Campylobacters, and other members of the classification, are small, gram-negative bacteria that are specially adapted to colonise the surface of the mucous membranes of the digestive tract. This is reflected in the morphology of the bacteria, which has a spiral-shaped body with long unsheathed flagella at each tip. Consequently, Campylobacter are highly motile, and are able to tunnel through the mucous layer and colonise the membrane below, which is a key ability as they are highly susceptible to acidity. They are partially anaerobic, alongside other members of the classification, and undergo transformation to coccoid forms when exposed to adverse conditions (Moran 1987). Presently, 18 subspecies of Campylobacter have been identified and 11 of these are thought to be pathogenic in humans. By far the most common are campylobacter jejuni and campylobacter coli; together, these bacteria are a leadi ng cause of diarrhoeal illness. Principal risk factors for infection with campylobacter jejuni include the consumption of undercooked meat, especially poultry, inadequately pasteurised milk, contaminated water and pets with diarrhoea (Gillespie 2008). There may be human-human transmission via the faeco-oral route if personal hygiene is unsatisfactory (Wilson 2008). There is an incubation period of around 3 days, though this can range from 1-7 days. There is occasionally a prodromal illness of fever, myalgia and headache lasting around 24 hours, and patients who present with the prodromal illness often have a more severe infection than those presenting with gastrointestinal symptoms (Minton 2004). The principal illness is characterised by colicky, periumbical abdominal pain, pyrexia (the fever may be as high as 40à ¢? °C) and profuse diarrhoea, often with up to 10 bowel movements each day. The stool may be watery initially, and blood may appear in the stool as the infection progresses. Around 25% of patients will experiences tenesmus (Minton 2004). Symptoms of diarrhoea generally last for up to 7 days, and abdominal pain may persist a little longer. The illness is generally self-limiting, though the prognosis can be worse in the very young, the elderly, those with comorbid condition and the immunocompromised (Nelson 2004). It is not possible to differentiate campylobacter infection from other causes of infective gastroenteritis based on history and examination findings alone (Buss 2015). Therefore, detection of campylobacter in a stool sample is the mainstay of diagnosis, though a negative sample cannot exclude the presence of campylobacter. Samples are rarely positive after two weeks. Stool samples should always be collected in patients presenting with these symptoms, as infection with campylobacter is a notifiable disease in England and Wales (NICE 2014). In a generally fit and well adult, the main risk of acute diarrhoea of any cause, inclu ding campylobacter, is dehydration. Therefore, maintaining adequate hydration is the cornerstone of treatment. This can generally be achieved by increasing oral fluid intake, but in vulnerable patients intravenous hydration may be indicated. Rehydration may be encouraged with the administration of Racecadotril. Racecadotril is an intestinal antisecretory enkephalinase inhibitor that inhibits the breakdown of endogenous enkephalins, reducing the hypersecretion of water and electrolytes into the intestine (NICE 2013). Racecadotril is licensed in the United Kingdom for the complimentary treatment of acute diarrhoea in patients aged greater than 3 months, together with oral rehydration. Though the symptoms of campylobacter infection are unpleasant and inconvenient, there is generally no indication for antimotility medications. In fact, unless the diagnosis is confirmed via the laboratory, these medications are contraindicated as toxic megacolon has been reported as an adverse effect of antimotility medications in patients with pseudomembranous colitis and inflammatory bowel disease (Minton 2004). Given the short duration and self-limiting nature of the condition, antibiotic therapy is generally not recommended. A Swedish meta-analysis of eleven randomised control trials reported that, versus placebo, antimicrobial therapy reduced the duration of intestinal symptoms by only 1.3 days (95% CI 0.6-2.0 days) (Ternhag 2007). A further review by the National Institute of Health and Care Excellence (NICE) reported that antibiotic treatment with erythromycin cleared the bacteria from stool samples rapidly, but had no effect on the course of the disease (NICE 2009). Problems exist with antibiotic-resistant species of campylobacter, largely due to antibiotic use in animals (Gallay 2007; Lehtopolko 2010). However, antibiotic therapy should be considered for patients with severe disease or at risk of severe disease. Patients with severe disease include individuals wit h bloody stools, high fever, extra intestinal infection, worsening or relapsing symptoms, or symptoms lasting longer than one week (Ruiz-Palacios 2007). Patients classified as at risk of severe disease include the immunocompromised, the elderly and pregnant women. NICE supports this, suggesting that antibiotic therapy may be indicated if any of the following occur (NICE 2014): High fever Bloody diarrhoea More than eight stools daily Worsening clinical condition Illness for over a week Pregnancy Immunocompromise Should an antibiotic be required, azithromycin and erythromycin are the most effective agents against campylobacter in the UK, with a single 30mg/kg dose of azithromycin early in the disease proving just as effective as a 5 day course of erythromycin (Vukelic 2010). The British National Formulary recommends a combination therapy of clarithromycin with ciprofloxacin as an alternative. There are a number of complications of campylobacter infection. Acute bacterial gastroenteritis has been linked with the onset of irritable bowel syndrome in around 15% of cases à ¢Ã¢â€š ¬Ã¢â‚¬Å" this is termed post-infective IBS (Smith 2007). Further complications include Reiters Syndrome (a form of reactive arthritis characterised by urethritis, conjunctivitis and arthritis), and the neurological condition Guillain-Barre Syndrome. In summary, campylobacter jejuni is a gram negative, spiral shaped bacteria that colonises the mucous membranes of the gut. This colonisation produces a self-limitin g illness characterised by fever, cramping abdominal pains and diarrhoea. Infection is diagnosed via detection of the bacteria in a sample of faeces. The mainstay of treatment is rehydration à ¢Ã¢â€š ¬Ã¢â‚¬Å" antibiotics are rarely indicated. References Buss S, Leber A, Chapin K, Fey P, Bankowski M, Jones M, Rogatcheva M, Kanack K, Bourzac K. (2015). Multicenter Evaluation of the BioFire FilmArray Gastrointestinal Panel for Etiologic Diagnosis of Infectious Gastroenteritis. Journal of Clinical Microbiology. 53(3) Butzler J-P 2004 Campylobacter, from obscurity to celebrity. Clinical Microbiology and Infection 10(10) Dekeyser, P, Gossuin-Detrain, M, Butzler, JP, and Sternon, J. 1972 Acute enteritis due to a related vibrio: first positive stool cultures. Journal of Infectious Diseases 125 Escherich, T. 1886 Beitrage zur Kenntniss der Darmbacterien. III. Ueber das Vorkommen von Vibrionen im Darmcanal und den Stuhlgangen der Sauglinge. (Articles adding to the knowledge of intestinal bacteria. III. On the existence of vibrios in the intestines and feces of babies.). MÃÆ' ¼nchener Med Wochenschrift. 33 Gallay A, Prouzet-MaulÃÆ' ©on V, Kempf I, Lehours P, Labadi L, Camou C, Denis M, de Valk H, Desenclos JC, MÃÆ' ©grau d F. 2007 Campylobacter antimicrobial drug resistance among humans, broiler chickens, and pigs, France. Emerging Infectious Diseases 13(2) Gillespie L, OBrien S, Penman C, Tomkins D, Cowden J, Humphrey T. 2008 Demographic determinants for Campylobacter infection in England and Wales: implications for future epidemiological studies. Epidemiology and Infection 136(12) Lehtopolku M, Nakari UM, Kotilainen P, Huovinen P, Siitonen A, Hakanen AJ. 2010 Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. Antimicrobial Agents and Chemotherapy 54(3) Minton J, Stanley P. 2004 Intra-Abdominal Infections. Clinical Medicine 4(6) Moran AP, Upton ME 1987 Factors affecting production of coccoid forms by Campylobacter jejuni on solid media during incubation. Journal of Applied Bacteriology 62(6) Nelson JM, Smith KE, Vugia DJ, Rabatsky-Ehr T, Segler SD, Kassenborg HD, Zansky SM, Joyce K, Marano N, Hoekstra RM, Angulo FJ. 2004 Prolonged diarrhea due to ciprofloxacin-resistant campylobacter infection. Journal of Infectious Diseases 190(6) NICE. (2013). Acute diarrhoea in children: racecadotril as an adjunct to oral rehydration. Available: https://www.nice.org.uk/advice/esnm12. Last accessed March 23rd 2015. NICE. (2009). CG84 Diarrhoea and vomiting in children: Diarrhoea and vomiting caused by gastroenteritis: diagnosis, assessment and management in children younger than 5 years. Available: https://www.nice.org.uk/guidance/cg84. Last accessed March 23rd 2015. NICE. (2014). Gastroenteritis. Available: https://cks.nice.org.uk/gastroenteritis. Last accessed March 23rd 2015. Ruiz-Palacios GM 2007. The health burden of Campylobacter infection and the impact of antimicrobial resistance: playing chicken. Clinical Infectious Diseases 44(5) Smith JL, Bayles D. 2007 Postinfectious irritable bowel syndrome: a long-term consequence of bacterial gastroenteritis. Journal of Food Protection 70(7) Ternhag A, Asikainen T, Giesecke J, Ekdahl K. 2007 A meta-analysis on the effects of antibiotic treatment on duration of symptoms caused by infection with Campylobacter species. Clinical Infectious Diseases 44(5) Vandamme P, Falsen E, Rossau R, Hoste B, Segers P, Tytgat R, De Ley J 1991 Revision of Campylobacter, Helicobacter, and Wolinella taxonomy: emendation of generic descriptions and proposal of Arcobacter gen. nov. International Journal of Systematic Bacteriology 41(1) Vukelic D, Trkulja V, Salkovic-Petrisic M. 2010 Single oral dose of azithromycin versus 5 days of oral erythromycin or no antibiotic in treatment of campylobacter enterocolitis in children: a prospective randomized assessor-blind study. Journal of Pedatric Gastroenterology and Nutrition 50(4) Wilson D, Gabriel E, Leatherbarrow A, Cheesbrough J, Gee S, Bolton E, Fox A, Fearnhead P, Hart C, Diggle P. 2008 Tracing the Source of Campylobacteriosis. PLoS Genetics 26; 4(9)

Finding the Best Optional Essay Mba Samples

Finding the Best Optional Essay Mba Samples Lies You've Been Told About Optional Essay Mba Samples People are unable to manage two squares of meals daily. Real individuals are reading your program, and we would like to do our very best to understand and appreciate the actual individuals applying to Duke. There's a correct method to inform your story. The title should stick out from the remainder of the text. As you proceed through the procedure, you will understand a more powerful, logical and impactful version emerging. The Bizarre Secret of Optional Essay Mba Samples In an identical purchase form, you're offer your name, email, and contact form. For some, the information included in the resume may appear redundant. Please limit your additional info to the space in this part. Don't neglect to include all the required information. Because the essay is open-ended you may also utilize it to bring any extra information you wished to inform the admissions committee about. Seriously, there are dozens and dozens of applicants and if you don't express your necessity your application will wind up lying with all the rest weak entries. In rare instances, MBA programs do not demand test scores of any applicants. Consult your mentor or admissions consultant, but the next template mig ht enable you to get started. The One Thing to Do for Optional Essay Mba Samples You don't need to lose different applicants only because you neglect to satisfy important deadlines or lack enough time to do your very best. An MBA is a vital part of my career objectives, and as such plays a crucial part in achieving my life objectives. Simply take a GMAT practice test with us under the exact conditions as the actual thing. In the event the rest of the application does a superior job for a candidate, then leave out the optional essay, explains Alex. It isn't an essay that needs to be used, if there is not any reason to utilize it. A standard result can make a weak supplemental essay. You may be thinking that everything sounds fantastic, and that what sounds best is you don't in fact have to compose the optional essay. If you are searching for assistance with your essay then we provide a comprehensive writing service given by fully qualified academics in your area of study. Whether you opt to compose an essay or prepare a presentation, have a step back from the distinctive format and consider the question strategically. When you finish the essay writing procedure, you are going to have crystal clear understanding on what is missing in your application. The only key isn't to use the optional essay only for the interest of using it. Understanding of vital components of succeeding from the very inception will result in the life objectives and plans formation. Simply speaking, it's simple to observe how commitment to an idea provides an extensive collection of possibilities to showcase various elements of your candidacy. Don't just lob in a wonderful story, since you can. The problem of unemployment isn't a little problem that might be easily uprooted by the society. If you take care of this, you run the chance of harming your general application. While applying, you might experience that the application procedure can be taxing. Many people losses their employment as a result of this reason. On the reverse side, if you're able to answer the question in four sentences, you can want to put a bit more thought into it. If it is possible to clarify and offer the required context in merely a few sentences, do that. If you just need a couple of sentences to receive your point across, then do so. The sentences should be short, unambiguous and offer the reader with a transparent comprehension of any upcoming action to take. Ok, I Think I Understand Optional Essay Mba Samples, Now Tell Me About Optional Essay Mba Samples! Please resist the need to include things like an essay you already wrote for another school. The optional essay may also demonstra te that you're seriously interested in attending a specific law school. Like a good deal of other small business schools, Babson gives you the chance to submit an optional essay, in other words, an essay as well as the three required. Simply state which you were not mature enough to concentrate on academics early in college and supply an illustration of how you're now ready for rigorous academic work.

Why Napoleon Is Bad Free Essays

Hello comrades, today right this second, I am supporting Snowball because he is not a thieving liar, a pig of trust and a pig with honor. He is the real pig behind the farm; not Napoleon. He has saved many animals during the Battle of Cowshed and he too shed blood. We will write a custom essay sample on Why Napoleon Is Bad or any similar topic only for you Order Now Napoleon, he is the real liar he has done nothing contributing to the leadership of the society! He is the traitor and not Snowball because he is the one with the ideas and with his heart so bright; brighter than the sun. His heart so pure, the purest even. And we have Napoleon. His heart so dark and evil it almost conceals him and no light can even be seen in his heart. We cannot trust this man of hell. He is the fake leader of this movement, he is not kind, he will never careless about the animals and he will never be pure of heart because he is consumed by the evil within him the greed, the thirst for power, the abuse of power he has acquired. He will have a tongue of lies which god may even curse and a life full of sin ahead of him. I do not encourage the leadership of Napoleon. In stead I would let Snowball a true believer take on the challenge because I feel that he who is pure at heart will be our leader and not a pig with a thirst for too much power. And when either takes over who shall be the one? My guess is simple. Snowball the Great Leader. He is the one who fought bravely for the animals, the one who loves the animals to heart’s content! He is not a coward, not an idiot and down to earth and he deserves your support and he does not deserve Napoleon to backstab him! He is the very best of his league the very best strategist. The animals are not doing this for fun! They are doing it for the sake of their society everything they do is for them and they deserve a leader like Snowball. They deserve better! They deserve the intellectual Snowball he always looked at other ways to solve problems and never failed! He is the chosen one. He is the one who will lead for the future. He is pure. He is not one of those people who would not give a damn if someone was hurt he is caring and he is honest that is the best thing about him. He has chased our beloved Snowball of the farm! EVEN THAT SHOULD BE A SIGN! He is the traitor! He must be subjected to mutiny! Throw him in the pits at the least! He has done nothing for the people but only for his own affairs! They do not accept domination over the animals they are all EQUAL! No one will be unequal! No one shall have more power than others! No animal shall have as much power as the humans because they themselves have seen how power has corrupted the human race! They are against the policy to be unequal are they not? Or are we just slaves to our own kind? It is up to you! But I say HE IS EVIL! Snowball believes in equality does he not? He protected them! Until this tyrant has taken over and put their days of Jones back in action! Napoleon believes in creating fear! And using the animals for himself! He trained the dogs for his own protection not for theirs! The creator of this revolution has blessed Snowball! Old Major himself! Do not forget what they stand for! Do not forget how they must stand for their principles! DO NOT TRUST THE TRAITOR! DO NOT FOLLOW HIS TYRANNICAL JUDGEMENT! He has killed! Is that not against the 7 Commandments? He sleeps in a bed too and influenced the pigs that were not corrupt! He is not to be trusted! Not to be trusted with power of the country! And their leader abuses the power! Snowball would never do that! He would never give into corruption! He was the best, one and only true leader of this movement! Cheers. How to cite Why Napoleon Is Bad, Essay examples